By Icon Health Publications
This can be a 3-in-1 reference ebook. It offers a whole clinical dictionary masking 1000s of phrases and expressions when it comes to acute myelogenous leukemia. It additionally provides huge lists of bibliographic citations. ultimately, it presents info to clients on tips to replace their wisdom utilizing numerous web assets. The ebook is designed for physicians, scientific scholars getting ready for Board examinations, scientific researchers, and sufferers who are looking to familiarize yourself with examine devoted to acute myelogenous leukemia. in the event that your time is efficacious, this e-book is for you. First, you won't waste time looking the web whereas lacking loads of suitable info. moment, the e-book additionally saves you time indexing and defining entries. eventually, you won't waste time and cash printing hundreds and hundreds of web content.
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Additional info for Acute Myelogenous Leukemia - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
The PLZF protein contains an evolutionarily conserved motif called a POZ (poxvirus zinc finger) domain, found in other zinc finger proteins implicated in neoplasia, development and differentiation. The POZ domain appears to be necessary for PLZF protein to dimerize and repress gene transcription and for the transcriptional and biological effects of PLZF and the PLZF-RARa chimera. The mode of action and molecular target proteins of the POZ domains are unknown. The proposed research will: 1. Determine of how PLZF controls myeloid cell growth and differentiation by elucidation of PLZF target genes which bind the PLZF protein in vitro and in vivo such as IL-6, cyclin A and other to be identified by whole genome PCR.
Dana-Farber Cancer Institute 44 Binney St Boston, Ma 02115 Timing: Fiscal Year 2002; Project Start 30-SEP-1986; Project End 31-DEC-2002 Summary: The principal activity of this grant is to improve the care and treatment of children with cancer by participating in the Pediatric Oncology Group (POG). The three specific goals of the participation of the Dana-Farber Cancer Institute/Children's Hospital (DFCI/CH) and Maine Children's Cancer Program (MCCP) are to 1) enter and follow children with malignancies on appropriate Pediatric Oncology Group (POG) protocols 2) provide leadership in planning and executing POG protocols and 3) provide pilot clinical studies and scientific leadership to POG.
3) To study PML phosphorylation and the biologic significance. Hypothesis to be tested: Phosphorylation and dephosphorylation of the PML protein play an important role in the regulation of cell cycle progression, apoptosis, and transcription regulation. Studies outlined in this proposal will provide important information toward understanding cell cycle regulation and apoptosis. Results obtained from these studies will further expand our knowledge in understanding the molecular pathology of acute promyelocytic leukemia.